Latest Conference Articles

The OncLive® Conference page includes a listing of all conferences covered by OncLive®, including the ASCO, ESMO, SITC, EHA, ASH, and SABCS annual meetings, as well as the Chemotherapy Foundation Symposium and Miami Breast Cancer Conference, among many others. Conference coverage incorporates articles and interviews in written and video format.

CAR T-Cell Therapy Elicits High Response Rate in Pediatric ALL

CAR T-Cell Therapy Elicits High Response Rate in Pediatric ALL

December 7th 2014

The anti-CD19 chimeric antigen receptor-modified T-cell therapy CTL019 demonstrated an impressive 92% complete response rate in pediatric patients with relapsed/refractory acute lymphoblastic leukemia.

Dr. Farhad Ravandi Discusses Vosaroxin in the VALOR Trial

Dr. Farhad Ravandi Discusses Vosaroxin in the VALOR Trial

December 7th 2014

Farhad Ravandi, MD, from the University of Texas MD Anderson Cancer Center in Houston, describes results from the phase III VALOR trial that explored vosaroxin plus cytarabine versus placebo and cytarabine in patients with first relapsed or refractory acute myeloid leukemia.

Frontline Idelalisib Monotherapy Yields High Response Rates in Older Patients With CLL, SLL

Frontline Idelalisib Monotherapy Yields High Response Rates in Older Patients With CLL, SLL

December 7th 2014

Idelalisib monotherapy shows activity in treatment-naïve patients ≥65 years with CLL or SLL, with nearly 90% of patients enrolled in a phase II study demonstrating a partial response.

Dr. Eytan Stein Discusses the IDH2 Inhibitor AG-221 in AML

Dr. Eytan Stein Discusses the IDH2 Inhibitor AG-221 in AML

December 7th 2014

Eytan Stein, MD, from the Memorial Sloan Kettering Cancer Center, discusses new data from a phase I study exploring the oral IDH2 inhibitor AG-221 in patients with advanced hematologic malignancies, primarily acute myelogenous leukemia and myelodysplastic syndrome.

Brentuximab Vedotin Delivers Unprecedented Post-Transplant  PFS Benefit in Relapsed Hodgkin Lymphoma

Brentuximab Vedotin Delivers Unprecedented Post-Transplant PFS Benefit in Relapsed Hodgkin Lymphoma

December 7th 2014

Patients with relapsed and difficult-to-treat Hodgkin lymphoma who received brentuximab vedotin had an unprecedented 50% higher likelihood of continuing to experience PFS at 2 years.

Anti-CD38 Antibodies Highly Effective in Multiple Myeloma

Anti-CD38 Antibodies Highly Effective in Multiple Myeloma

December 7th 2014

Two studies spotlighted at the 2014 ASH Annual Meeting characterized the efficacy of treatment with anti-CD38 monoclonal antibodies in the frontline setting and for patients with refractory disease.

Carfilzomib Combination Significantly Increases PFS in Relapsed Multiple Myeloma

Carfilzomib Combination Significantly Increases PFS in Relapsed Multiple Myeloma

December 7th 2014

Treatment with carfilzomib in combination with lenalidomide and dexamethasone increased PFS by 8.7 months in patients with relapsed multiple myeloma when compared with lenalidomide and dexamethasone alone.

Pembrolizumab Elicits Responses in Classical Hodgkin Lymphoma

Pembrolizumab Elicits Responses in Classical Hodgkin Lymphoma

December 7th 2014

Treatment with the PD-1 inhibitor pembrolizumab generated responses in 66% of patients with heavily pretreated classical Hodgkin lymphoma.

Blinatumomab Leads to High MRD Response in B-Precursor ALL

Blinatumomab Leads to High MRD Response in B-Precursor ALL

December 7th 2014

At least 80% of patients with B-precursor acute lymphoblastic leukemia had a complete minimal residual disease response after a single cycle of treatment with the CD19-directed antibody blinatumomab.

Nivolumab Achieves Encouraging Responses in Refractory Classical Hodgkin Lymphoma

Nivolumab Achieves Encouraging Responses in Refractory Classical Hodgkin Lymphoma

December 6th 2014

In a small phase I trial, most patients with classical Hodgkin lymphoma, having previously failed three or more therapies, responded to the immunotherapy nivolumab.

Dr. Stewart Discusses the Efficacy of Carfilzomib in the ASPIRE Trial

Dr. Stewart Discusses the Efficacy of Carfilzomib in the ASPIRE Trial

December 6th 2014

A. Keith Stewart, MBChB, from the Mayo Clinic in Scottsdale, Arizona, discusses findings from the phase III ASPIRE trial that evaluated the novel proteasome inhibitor carfilzomib in combination with lenalidomide and dexamethasone for patients with relapsed multiple myeloma.

Dr. Grupp on Optimal Treatment Settings for CAR-Modified T Cells

Dr. Grupp on Optimal Treatment Settings for CAR-Modified T Cells

December 6th 2014

Stephan Grupp, MD, PhD, of the Children's Hospital of Philadelphia, discusses the optimal treatment settings for novel CD19-specific CAR-modified T cell therapies in patients with acute lymphoblastic leukemia.

ASH 2014 Preview: Checkpoint Inhibition, CAR Modified T Cells, and Novel Therapies

ASH 2014 Preview: Checkpoint Inhibition, CAR Modified T Cells, and Novel Therapies

December 1st 2014

The top research being presented at the 2014 American Society of Hematology Annual Meeting will focus on immunotherapies and novel agents, according to Marcel R.M. van den Brink, MD, PhD.

Dr. van den Brink Highlights Five Abstracts From ASH 2014

Dr. van den Brink Highlights Five Abstracts From ASH 2014

December 1st 2014

Marcel R.M. van den Brink, MD, PhD, Head, Division of Hematologic Oncology, Memorial Sloan Kettering Cancer Center, provides an overview of five notable studies being presented at the 2014 American Society of Hematology (ASH) Meeting and Exposition.

Dr. Herbst Discusses the State of Immunotherapy in Lung Cancer

Dr. Herbst Discusses the State of Immunotherapy in Lung Cancer

November 18th 2014

Roy S. Herbst, MD, PhD, professor, Yale Cancer Center, chief of medical oncology, Smilow Cancer Hospital at Yale-New Haven, discusses the state of immunotherapy in lung cancer.

Experts Discuss Immunotherapy's Potential in Neuro-Oncology

Experts Discuss Immunotherapy's Potential in Neuro-Oncology

November 17th 2014

Immunotherapy's promise as well as its challenges as a treatment for patients with brain cancer was the focus of a plenary session held November 15 at the Society of Neuro-Oncology's (SNO) 2014 Annual Meeting in Miami Beach.

Dr. Raizer Discusses Proton Therapy for Glioma

Dr. Raizer Discusses Proton Therapy for Glioma

November 17th 2014

Jeffrey J. Raizer, MD, Co-Director, Northwestern Brain Tumor Institute, Professor in Neurology, Ken and Ruth Davee Department, Medicine-Hematology/Oncology, Northwestern University Feinberg School of Medicine, discusses a study that analyzed the overall survival and toxicity of proton therapy for large-volume re-irradiation for recurrent glioma.

Oncolytic Virus Shows Early Promise in Glioma

Oncolytic Virus Shows Early Promise in Glioma

November 17th 2014

The oncolytic virus Delta-24-RGD can infect, replicate, and kill glioma cells in patients, according to phase I research presented at the 2014 Society for Neuro-Oncology (SNO) Annual Meeting in Miami.

Dr. de Groot Discusses Altiratinib as Potential Treatment for Glioblastoma

Dr. de Groot Discusses Altiratinib as Potential Treatment for Glioblastoma

November 17th 2014

John F de Groot, MD, nuro-oncologist, MD Anderson Cancer Center, discusses the efficacy of the novel c-MET inhibitor altiratinib in glioblastoma.

Dr. Stupp Discusses NovoTTF With Temozolomide in Glioblastoma

Dr. Stupp Discusses NovoTTF With Temozolomide in Glioblastoma

November 16th 2014

Roger Stupp, MD, Professor of Oncology, University of Zürich; Chairman, Department of Oncology and Cancer Center, University of Zürich Hospital, Zürich, Switzerland, discusses the interim analysis of the EF-14 trial, which compared NovoTTF-100A together with temozolomide versus temozolomide alone in patients with newly diagnosed glioblastoma multiforme (GBM).

Survival Improvement With NovoTTF Leads to Early End of Phase III Trial

Survival Improvement With NovoTTF Leads to Early End of Phase III Trial

November 16th 2014

Use of the NovoTTF system along with adjuvant temozolomide led to longer progression-free survival and overall survival in patients with glioblastoma.

Dr. Butowski Discusses Dianhydrogalactitol in Patients with Recurrent GBM

Dr. Butowski Discusses Dianhydrogalactitol in Patients with Recurrent GBM

November 16th 2014

Nicholas Butowski, MD, associate professor, University of California, San Francisco, neuro-oncologist, UCSF Medical Center, discusses a phase I/II study of dianhydrogalacitol in patients with recurrent glioblastoma multiforme (GBM).

Rindopepimut Leads to Improved PFS in Compassionate Use Study

Rindopepimut Leads to Improved PFS in Compassionate Use Study

November 16th 2014

The vaccine rindopepimut appears to help PFS and OS in patients with epidermal growth factor receptor variant III mutation in glioblastoma-a patient group with traditionally poor outcomes.

Dr. van den Bent Discusses Bevacizumab Plus Lomustine in Recurrent Glioblastoma

Dr. van den Bent Discusses Bevacizumab Plus Lomustine in Recurrent Glioblastoma

November 15th 2014

Martin J. van den Bent, MD, professor, Neuro-Oncology, Erasmus MC-Daniel den Hoed Cancer Center, Rotterdam, the Netherlands, discusses the BELOB trial, which examined bevacizumab versus bevacizumab plus lomustine versus lomustine single agent in recurrent glioblastoma.

Ceritinib Effective in Patients With Brain Metastases

Ceritinib Effective in Patients With Brain Metastases

November 15th 2014

The next-generation ALK inhibitor ceritinib showed clinically significant antitumor activity in patients with ALK-rearranged NSCLC, including those with brain metastases.

Dr. Reardon Discusses Rindopepimut Plus Bevacizumab in Glioblastoma

Dr. Reardon Discusses Rindopepimut Plus Bevacizumab in Glioblastoma

November 15th 2014

David Reardon, MD, clinical director, Center for Neuro-Oncology, Dana-Farber Cancer Institute, president, Society for Neuro-Oncology, discusses the ReACT study, which examined the rindopepimut vaccine (CDX-110) plus bevacizumab in patients with relapsed glioblastoma.

Rindopepimut Plus Bevacizumab Shows Prolonged Survival in Recurrent Glioblastoma

Rindopepimut Plus Bevacizumab Shows Prolonged Survival in Recurrent Glioblastoma

November 15th 2014

The vaccine rindopepimut plus bevacizumab induced tumor regression in a subset of patients with recurrent glioblastoma.

Adding Lomustine to Bevacizumab Improves Outcomes in Recurrent Glioblastoma

Adding Lomustine to Bevacizumab Improves Outcomes in Recurrent Glioblastoma

November 14th 2014

The combination of bevacizumab and lomustine showed superior efficacy compared with either agent alone in patients with recurrent glioblastoma, warranting further study.

Dr. Verhaak Discusses Genomic Characterization of Diffuse Lower Grade Gliomas

Dr. Verhaak Discusses Genomic Characterization of Diffuse Lower Grade Gliomas

November 14th 2014

Roeland GW Verhaak, PhD, Assistant Professor, Department of Bioinformatics and Computational Biology, Division of Quantitative Sciences, The University of Texas MD Anderson Cancer Center, discusses a study that examined the comprehensive and integrative genomic characterization of diffuse lower grade gliomas.

PCV Chemotherapy Plus Radiation Improves Survival in Low-Grade Glioma

PCV Chemotherapy Plus Radiation Improves Survival in Low-Grade Glioma

November 14th 2014

The combination of radiation therapy with procarbazine, CCNU, and vincristine prolonged OS and PFS compared with radiation therapy alone in grade 2 glioma.