Vol. 20/No. 8 | OncologyLive

Direct Oral Anticoagulants Signal Change in VTE Prevention

April 16, 2019

Investigators at Cleveland Clinic have demonstrated that the direct oral anticoagulant rivaroxaban significantly reduces venous thromboembolism (VTE) and VTE-related death for patients with high-risk cancers treated in the outpatient setting.

Ivosidenib Holds Greatest Benefit for Older Patients With IDH1-Mutant AML

April 16, 2019

Courtney D. DiNardo, MD, MSCE, discusses the findings of the phase I dose-escalating study that led to the initial approval of ivosidenib for adult patients with relapsed or refractory acute myeloid leukemia with an IDH1 mutation.

Durvalumab Results Spark Hope for Progress in Advanced NSCLC

April 16, 2019

During an OncLive Peer Exchange® discussion, moderator Mark A. Socinski, MD, and other lung cancer experts from across the United States discuss what, in this context, the PACIFIC trial results mean for practicing oncologists and their patients.

Quizartinib Poised to Expand FLT3 Inhibition Options in AML

April 16, 2019

Quizartinib, a novel small molecule FLT3 inhibitor, is moving through the pipeline of new drugs under development for patients with FLT3-mutated acute myeloid leukemia, part of a menu of targeted treatment options that is expanding as investigators learn more about the molecular heterogeneity of the disease.

ATR Inhibitors Offer New Line of Attack on DNA Repair Network

April 12, 2019

Cancer cells that manipulate the DNA damage response to foster the genomic instability that underlies many of their hallmark processes become heavily reliant on intact pathways for their survival, creating a targetable Achilles heel that can be exploited therapeutically.

Genetic Testing Recommended for All Patients With Pancreatic Cancer

April 12, 2019

In a provisional clinical opinion, an expert panel convened by the American Society of Clinical Oncology has recommended that patients with pancreatic cancer undergo assessment of risk for hereditary syndromes that contribute to higher likelihood of pancreatic cancer.

Oral Anticoagulants Demonstrate Value in Management of Acute VTE

April 11, 2019

The optimal anticoagulant takes into consideration a variety of components, including patient preference, the indication for anticoagulation, comorbidities, reversibility, and other factors relevant to the clinical scenario.

Old-Fashioned Biology Trumps Technological Potential

April 10, 2019

The recent technological advances in medicine and related fields have encouraged a belief among many that there is little technology will not be able to accomplish in improving cancer-related clinical outcomes, but it must be acknowledged that clinical medicine and cancer biology are extremely complex arenas.