The Role of Allo-HSCT in Higher-Risk MDS

EP: 1.Role of Allogeneic Transplants in Hematologic Malignancies

EP: 2.Hematologic Malignancies and Transplant Options and Conditioning Regimens Used in Allo-HSCT

EP: 3.Supportive Care Measures for Patients Planning to Receive an Allogenic Transplant

EP: 4.Transplant Complications and Survival Outcomes

EP: 5.Clinical Trial Update: CTN Trial

EP: 6.Graft-versus-Host Disease Prophylaxis and Management

EP: 7.Patient Case Studies of GvHD

EP: 8.Emerging Cellular Therapies in Hematologic Malignancies

EP: 9.Transplant in the Elderly Population

EP: 10.Toxicity Assessment of Precision-Engineered Allo-HSCT

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EP: 11.The Role of Allo-HSCT in Higher-Risk MDS

EP: 12.Investigational Allo-HSCT for Advanced Hematologic Malignancies

EP: 13.The Future of Allo-HSCT and Cellular Therapies

EP: 14.OncLive Peer Exchange on Allo-HSCT: Conclusion of Discussion

This is a video synopsis/summary of a Peer Exchange featuring Miguel-Angel Perales, MD; Nelli Bejanyan, MD; Amandeep Salhotra, MD; and Arpita Gandhi, MD, MS.

Speakers discuss the role of Orca-T cell therapy (Orca-T) in myelodysplastic syndrome (MDS) and the importance of transplantation in this disease. Risk-stratification tools, particularly the molecular International Prognostic Scoring System-Revised score, are used to identify patients with moderate to high risk or very high-risk disease who have a dismal prognosis and a high risk of transformation to acute myeloid leukemia. Nontransplant strategies have not been very successful in improving outcomes for these patients, as demonstrated in the BMT CTN 1101 trial, where patients with donors had improved survival compared to those without donors. MDS is an approved indication for allogeneic hematopoietic stem cell transplantation (allo-HSCT) in patients with high-risk disease, who are often older than 60 years. Orca-T is considered an ideal graft manipulation strategy to reduce transplant-related mortality and improve relapse-free survival and overall survival. The speakers discuss an abstract evaluating 16 patients from the initial phase 1B study that showed promising results with minimal toxicities and a modified graft-vs-host disease (GVHD) rate of about 75%. They believe Orca-T takes MDS treatment to the next level and should be compared in the ongoing randomized phase 3 study.

Video synopsis is AI-generated and reviewed by OncLive® editorial staff.