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Opinion|Videos|January 27, 2025

Updates From VERSATILE-002: Pembrolizumab Plus PDS0101 (HPV-16–Targeted Cancer Vaccine) in HPV-Positive HNSCC

Author(s)Francis Paul Worden, MD, University of Michigan Comprehensive Cancer Center, Kevin Harrington, MBBS, MRCP, FRCR, FRCP, PhD, DIC

Panelists discuss how, PDS0101 uses Versamune® lipid nanoparticles to deliver HPV16 antigens, activating T-cells. Early Phase 2 data with pembrolizumab showed promise in HPV16+ head & neck cancer patients.

Episodes in this series

2 experts are featured in this series.

EP. 1 Introduction and Incidence of HPV-Positive Head and Neck Cancer

2 experts are featured in this series.

EP. 2 Understanding HPV-Positive HNSCC: Disease Presentation and Risk Factors

2 experts are featured in this series.

EP. 3 Navigating Treatment for HPV-Positive HNSCC Patients

2 experts are featured in this series.

EP. 4 Academic Perspectives for the Management of HPV-Positive HNSCC

2 experts are featured in this series.

EP. 5 Updates From VERSATILE-002: Pembrolizumab Plus PDS0101 (HPV-16–Targeted Cancer Vaccine) in HPV-Positive HNSCC

2 experts are featured in this series.

EP. 6 Emerging Phase 3 Trial: Pembrolizumab Plus PDS0101 (HPV-16 Targeted Cancer Vaccine) in HPV-Positive HNSCC (VERSATILE-003)

2 experts are featured in this series.

EP. 7 Treatment Insights for R/M HPV-Positive HNSCC

2 experts are featured in this series.

EP. 8 Future Considerations for the Treatment of R/M HPV-Positive HNSCC

Video content above is prompted by the following:

Please describe the mechanism of action of the novel Versamune (PDS0101) HPV-16 targeted cancer vaccine.
Please discuss the recent data presented for the Phase 2 VERSATILE-002 study of PDS0101 + pembrolizumab in adults with HPV16 and PD-L1 positive recurrent/metastatic HNSCC.
Weiss et al. ESMO 2024
Versatile-002 - 879P - ESMO 2024

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