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Opinion|Videos|January 20, 2025

Understanding HPV-Positive HNSCC: Disease Presentation and Risk Factors

Author(s)Francis Paul Worden, MD, University of Michigan Comprehensive Cancer Center, Kevin Harrington, MBBS, MRCP, FRCR, FRCP, PhD, DIC

Panelists discuss how, HPV-positive head and neck squamous cell carcinoma (HPV+ HNSCC) typically presents differently from HPV-negative cases. Patients often present with smaller primary tumors but more advanced nodal disease, commonly with cystic lymph node metastases in the neck. The most frequent site is the oropharynx, particularly the tonsils and base of tongue.

Episodes in this series

2 experts are featured in this series.

EP. 1 Introduction and Incidence of HPV-Positive Head and Neck Cancer

2 experts are featured in this series.

EP. 2 Understanding HPV-Positive HNSCC: Disease Presentation and Risk Factors

2 experts are featured in this series.

EP. 3 Navigating Treatment for HPV-Positive HNSCC Patients

2 experts are featured in this series.

EP. 4 Academic Perspectives for the Management of HPV-Positive HNSCC

2 experts are featured in this series.

EP. 5 Updates From VERSATILE-002: Pembrolizumab Plus PDS0101 (HPV-16–Targeted Cancer Vaccine) in HPV-Positive HNSCC

2 experts are featured in this series.

EP. 6 Emerging Phase 3 Trial: Pembrolizumab Plus PDS0101 (HPV-16 Targeted Cancer Vaccine) in HPV-Positive HNSCC (VERSATILE-003)

2 experts are featured in this series.

EP. 7 Treatment Insights for R/M HPV-Positive HNSCC

2 experts are featured in this series.

EP. 8 Future Considerations for the Treatment of R/M HPV-Positive HNSCC

Video content above is prompted by the following:

Understanding HPV+ HNSCC: Disease Presentation, and Risk Factors
How does HPV+ HNSCC typically present in patients, and how severe is the disease compared to HPV- cancers?
What are the key risk factors for developing HPV+ HNSCC, and how can they impact prognosis?

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