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Opinion|Videos|April 7, 2025

Cilta-cel vs. Ide-cel: Key Data Updates and Clinical Decision-Making in R/R MM

Author(s)Surbhi Sidana, MD, Peter Voorhees, MD

Experts discuss how they decide between utilizing cilta-cel vs ide-cel in multiple myeloma, considering factors like disease characteristics, patient factors, and product differences, while reviewing the final progression-free survival (PFS) analysis from the KarMMA-3 study with ide-cel and key takeaways from the ASH 2024 update on minimal residual disease (MRD) negativity rates from CARTITUDE-4 with cilta-cel and its impact on clinical practice.

Episodes in this series

EP. 1 Optimizing CAR T in R/R MM: Treatment Paradigms and Patient Selection

EP. 1 Optimizing CAR T in R/R MM: Treatment Paradigms and Patient Selection

EP. 2 Sequencing CAR T in More Heavily Pretreated R/R MM as well in patients who deferred initial autologous HSCT

EP. 2 Sequencing CAR T in More Heavily Pretreated R/R MM as well in patients who deferred initial autologous HSCT

EP. 3 Cilta-cel vs. Ide-cel: Key Data Updates and Clinical Decision-Making in R/R MM

EP. 3 Cilta-cel vs. Ide-cel: Key Data Updates and Clinical Decision-Making in R/R MM

EP. 4 Strategic Timing for CAR T in R/R MM: The Importance of Early Referral

EP. 4 Strategic Timing for CAR T in R/R MM: The Importance of Early Referral

EP. 5 Bridging to CAR T in R/R MM: Best Practices

EP. 5 Bridging to CAR T in R/R MM: Best Practices

EP. 6 Explaining CAR T: Key Points for Patient Counseling

EP. 6 Explaining CAR T: Key Points for Patient Counseling

EP. 7 Overcoming Barriers to CAR T Referral in R/R MM

EP. 7 Overcoming Barriers to CAR T Referral in R/R MM

EP. 8 Collaborative Approach in Managing Post CAR T Care Between Academic and Community Physicians in R/R MM

EP. 8 Collaborative Approach in Managing Post CAR T Care Between Academic and Community Physicians in R/R MM

EP. 9 Clinical Perspectives: Importance of Vaccinations and Infection Prevention Post CAR T, and Monitoring Strategies for Other Potential Late CAR T–Related Toxicities in R/R MM

EP. 9 Clinical Perspectives: Importance of Vaccinations and Infection Prevention Post CAR T, and Monitoring Strategies for Other Potential Late CAR T–Related Toxicities in R/R MM

EP. 10 Exciting Future Horizons for CAR T in MM and Take-Home Messages

EP. 10 Exciting Future Horizons for CAR T in MM and Take-Home Messages

Video content above is prompted by the following:

How are you deciding between utilizing cilta-cel vs ide-cel, and what factors (disease, patient, and/or product) impact that decision?
KarMMA-3 with ide-cel also recently reported its final PFS analysis. What were some highlights of this data, and what areyour impressions so far?
There was a recent update from ASH 2024 regarding the MRD negativity rates from CARTITUDE-4 with cilta-cel; what were some of your key takeaways, and have the data impacted your clinical practice?

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